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Plasma proteomic profiling in HIV-1 infected methamphetamine abusers.

ABSTRACT: We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.

SUBMITTER: Pottiez G

PROVIDER: S-EPMC3281056 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Plasma proteomic profiling in HIV-1 infected methamphetamine abusers.

Pottiez Gwenael G Jagadish Teena T Yu Fang F Letendre Scott S Ellis Ronald R Duarte Nichole A NA Grant Igor I Gendelman Howard E HE Fox Howard S HS Ciborowski Pawel P

PloS one 20120216 2

We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itse ...[more]

PMID: 22359561

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