Ontology highlight
ABSTRACT:
SUBMITTER: Kiran MS
PROVIDER: S-EPMC3045352 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kiran Manikantan S MS Viji Raveendran I RI Kumar Sameer Vb SV Prabhakaran Athira A AA Sudhakaran Perumana R PR
Vascular cell 20110214 1
The mechanism of cell-cell contact dependent regulation of pericellular proteolysis in angiogenesis was examined by studying the expression of MMPs using isolated HUVECs in culture. Zymography, Immunoblot and RT-PCR analysis showed that the production and secretion of matrixmetalloproteinase-2 and matrixmetalloproteinase-9 by HUVECs in culture were high when they remain as individual cells and significantly decreased during later stages of culture when cells developed cell-cell contact and tubul ...[more]