Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3045439 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Li Yao Y Guo Yunqian Y Wang Jianxin J Hou Wei W Chang Myron N MN Liao Duanping D Wu Rongling R
PloS one 20110225 2
Genomic imprinting is a phenomenon in which the same allele is expressed differently, depending on its parental origin. Such a phenomenon, also called the parent-of-origin effect, has been recognized to play a pivotal role in embryological development and pathogenesis in many species. Here we propose a statistical design for detecting imprinted loci that control quantitative traits based on a random set of three-generation families from a natural population in humans. This design provides a path ...[more]