Genomic imprinting: implications for human disease.
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ABSTRACT:
SUBMITTER: Falls JG
PROVIDER: S-EPMC1866410 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Publications
Genomic imprinting: implications for human disease.
Falls J G JG Pulford D J DJ Wylie A A AA Jirtle R L RL
The American journal of pathology 19990301 3
Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. This parent-of-origin dependent phenomenon is a notable exception to the laws of Mendelian genetics. Imprinted genes are intricately involved in fetal and behavioral development. Consequently, abnormal expression of these genes results in numerous human genetic disorders including carcinogenesis. This paper reviews genomic imprinting and its role in human disease. Additional information about impr ...[more]
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