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Facile amide formation via S-nitrosothioacids.

ABSTRACT: Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.

SUBMITTER: Pan J

PROVIDER: S-EPMC3045635 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Facile amide formation via S-nitrosothioacids.

Pan Jia J Devarie-Baez Nelmi O NO Xian Ming M

Organic letters 20110127 5

Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis. ...[more]

PMID: 21271725

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