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A gp63 based vaccine candidate against Visceral Leishmaniasis.

ABSTRACT: Visceral leishmaniasis is a macrophage associated disorder which leads to a profound decrease in the natural immunotherapeutic potential of the infected subjects to combat the disease. The major surface glycoprotein gp63 has been found to be a significant vaccine candidate against visceral leishmaniasis. The current study addresses the levels of similarity and identity in the gp63 obtained from different species of Leishmania viz donovoni, chagasi and infantum linked to the cause of visceral leishmaniasis. The results from BLAST, Phylogram and Cladogram studies indicate significant identity, similarity and conservation of important residues in the protein which lead us to conclude that a common gp63 based vaccine can be used as a therapeutical tool against visceral leishmaniasis caused by different species strains of leishmania.

SUBMITTER: Sinha S

PROVIDER: S-EPMC3046035 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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A gp63 based vaccine candidate against Visceral Leishmaniasis.

Sinha Sukrat S Sundaram Shanthy S Singh Anand Prakash AP Tripathi Ashutosh A

Bioinformation 20110122 8

Visceral leishmaniasis is a macrophage associated disorder which leads to a profound decrease in the natural immunotherapeutic potential of the infected subjects to combat the disease. The major surface glycoprotein gp63 has been found to be a significant vaccine candidate against visceral leishmaniasis. The current study addresses the levels of similarity and identity in the gp63 obtained from different species of Leishmania viz donovoni, chagasi and infantum linked to the cause of visceral lei ...[more]

PMID: 21383918

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