Ontology highlight
ABSTRACT:
SUBMITTER: Kumar R
PROVIDER: S-EPMC2861380 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kumar Rajiv R Goto Yasuyuki Y Gidwani Kamlesh K Cowgill Karen D KD Sundar Shyam S Reed Steven G SG
The American journal of tropical medicine and hygiene 20100501 5
People cured from visceral leishmaniasis (VL) develop protection mediated by Th1-type cellular responses against new infections. We evaluated cytokine responses against 6 defined candidate vaccine antigens in 15 cured VL subjects and 5 healthy endemic controls with no evidence of previous exposure to Leishmania parasites. Of the 6 cytokines examined, only interferon-gamma (IFN-gamma) differentiated cured VL patients from non-exposed individuals, with cured patients mounting a significantly highe ...[more]