Ontology highlight
ABSTRACT:
SUBMITTER: Murata RM
PROVIDER: S-EPMC3047413 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Murata Ramiro M RM Branco-de-Almeida Luciana S LS Franco Eliane M EM Yatsuda Regiane R dos Santos Marcelo H MH de Alencar Severino M SM Koo Hyun H Rosalen Pedro L PL
Biofouling 20101001 7
7-Epiclusianone (7-epi), a novel naturally occurring compound isolated from Rheedia brasiliensis, effectively inhibits the synthesis of exopolymers and biofilm formation by Streptococcus mutans. In the present study, the ability of 7-epi, alone or in combination with fluoride (F), to disrupt biofilm development and pathogenicity of S. mutans in vivo was examined using a rodent model of dental caries. Treatment (twice-daily, 60s exposure) with 7-epi, alone or in combination with 125 ppm F, result ...[more]