Ontology highlight
ABSTRACT:
SUBMITTER: Sahni J
PROVIDER: S-EPMC3047620 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sahni Jaya J Tamura Richard R Sweet Ian R IR Scharenberg Andrew M AM
Cell cycle (Georgetown, Tex.) 20100925 17
A unique property of lymphocytes among all body tissues is their capacity for rapid proliferation in the context of responding to infectious challenges. Lymphocyte proliferation involves a transition from a quiescent metabolic state adjusted to maintain cellular energy homeostasis, to a proliferative metabolic state in which aerobic glycolysis is used to generate energy and biosynthetic precursors necessary for the accumulation of cell mass. Here we show that modulation of TRPM7 channel function ...[more]