Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC3292586 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Liu Wei W Su Li-Ting LT Khadka Deepak K DK Mezzacappa Courtney C Komiya Yuko Y Sato Akira A Habas Raymond R Runnels Loren W LW
Developmental biology 20101209 2
During gastrulation, cells in the dorsal marginal zone polarize, elongate, align and intercalate to establish the physical body axis of the developing embryo. Here we demonstrate that the bifunctional channel-kinase TRPM7 is specifically required for vertebrate gastrulation. TRPM7 is temporally expressed maternally and throughout development, and is spatially enriched in tissues undergoing convergent extension during gastrulation. Functional studies reveal that TRPM7's ion channel, but not its k ...[more]