Ontology highlight
ABSTRACT:
SUBMITTER: Parathath SR
PROVIDER: S-EPMC3047755 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Parathath Susana R SR Mainwaring Lori Anne LA Fernandez-L Africa A Guldal Cemile G CG Nahlé Zaher Z Kenney Anna Marie AM
Cell cycle (Georgetown, Tex.) 20101011 19
Development of the cerebellum, a brain region regulating posture and coordination, occurs post-natally and is marked by rapid proliferation of granule neuron precursors (CGNPs), stimulated by mitogenic Sonic hedgehog (Shh) signaling. β-Arrestin (βArr) proteins play important roles downstream of Smoothened, the Shh signal transducer. However, whether Shh regulates βArrs and what role they play in Shh-driven CGNP proliferation remains to be determined. Here, we report that Shh induces βArr1 accumu ...[more]