Ontology highlight
ABSTRACT:
SUBMITTER: Bok J
PROVIDER: S-EPMC3752254 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Bok Jinwoong J Zenczak Colleen C Hwang Chan Ho CH Wu Doris K DK
Proceedings of the National Academy of Sciences of the United States of America 20130805 34
Neural precursor cells of the central nervous system undergo successive temporal waves of terminal division, each of which is soon followed by the onset of cell differentiation. The organ of Corti in the mammalian cochlea develops differently, such that precursors at the apex are the first to exit from the cell cycle but the last to begin differentiating as mechanosensory hair cells. Using a tissue-specific knockout approach in mice, we show that this unique temporal pattern of sensory cell deve ...[more]