Ontology highlight
ABSTRACT:
SUBMITTER: Sim AY
PROVIDER: S-EPMC3048103 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Sim Adelene Y L AY Levitt Michael M
Proceedings of the National Academy of Sciences of the United States of America 20110211 9
RNA often folds hierarchically, so that its sequence defines its secondary structure (helical base-paired regions connected by single-stranded junctions), which subsequently defines its tertiary fold. To preserve base-pairing and chain connectivity, the three-dimensional conformations that RNA can explore are strongly confined compared to when secondary structure constraints are not enforced. Using three examples, we studied how secondary structure confines and dictates an RNA's preferred confor ...[more]