Ontology highlight
ABSTRACT:
SUBMITTER: Zuo T
PROVIDER: S-EPMC3048165 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cancer research 20110107 5
Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tumorigenesis. However, molecular mechanisms underlying the complex interplay between the two marks remain to be explored. Here we show that activation of PI3K/AKT signaling can be a trigger of this epigenetic processing at many downstream target genes. W ...[more]