Ontology highlight
ABSTRACT:
SUBMITTER: Hontecillas R
PROVIDER: S-EPMC3049196 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Hontecillas R R Horne W T WT Climent M M Guri A J AJ Evans C C Zhang Y Y Sobral B W BW Bassaganya-Riera J J
Mucosal immunology 20101110 3
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IBD. This study aimed to characterize the mechanisms underlying the beneficial effects of macrophage PPAR-γ in IBD. Macrophage-specific PPAR-γ deletion significantly exacerbated clini ...[more]