Ontology highlight
ABSTRACT:
SUBMITTER: Bhaskara V
PROVIDER: S-EPMC3050042 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20070301 5
Mre11 and Rad50 are the catalytic components of a highly conserved DNA repair complex that functions in many aspects of DNA metabolism involving double-strand breaks. The ATPase domains in Rad50 are related to the ABC transporter family of ATPases, previously shown to share structural similarities with adenylate kinases. Here we demonstrate that Mre11/Rad50 complexes from three organisms catalyze the reversible adenylate kinase reaction in vitro. Mutation of the conserved signature motif reduces ...[more]