Ontology highlight
ABSTRACT:
SUBMITTER: Lim HS
PROVIDER: S-EPMC3093124 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Lim Hye Seong HS Kim Jin Seok JS Park Young Bong YB Gwon Gwang Hyeon GH Cho Yunje Y
Genes & development 20110421 10
Communication between Mre11 and Rad50 in the MR complex is critical for the sensing, damage signaling, and repair of DNA double-strand breaks. To understand the basis for interregulation between Mre11 and Rad50, we determined the crystal structure of the Mre11-Rad50-ATPγS complex. Mre11 brings the two Rad50 molecules into close proximity and promotes ATPase activity by (1) holding the coiled-coil arm of Rad50 through its C-terminal domain, (2) stabilizing the signature motif and P loop of Rad50 ...[more]