Ontology highlight
ABSTRACT:
SUBMITTER: Choi CH
PROVIDER: S-EPMC3050427 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Choi Catherine H CH Schoenfeld Brian P BP Bell Aaron J AJ Hinchey Paul P Kollaros Maria M Gertner Michael J MJ Woo Newton H NH Tranfaglia Michael R MR Bear Mark F MF Zukin R Suzanne RS McDonald Thomas V TV Jongens Thomas A TA McBride Sean M J SM
Brain research 20101112
Fragile X syndrome is the leading single gene cause of intellectual disabilities. Treatment of a Drosophila model of Fragile X syndrome with metabotropic glutamate receptor (mGluR) antagonists or lithium rescues social and cognitive impairments. A hallmark feature of the Fragile X mouse model is enhanced mGluR-dependent long-term depression (LTD) at Schaffer collateral to CA1 pyramidal synapses of the hippocampus. Here we examine the effects of chronic treatment of Fragile X mice in vivo with li ...[more]