Ontology highlight
ABSTRACT:
SUBMITTER: Eng AG
PROVIDER: S-EPMC5133636 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Eng Andrew G AG Kelver Daniel A DA Hedrick Tristan P TP Swanson Geoffrey T GT
Nature communications 20161125
Conventional signalling by the group I metabotropic glutamate receptors, mGluR1 and mGluR5, occurs through G-protein coupling, but evidence suggests they might also utilize other, non-canonical effector pathways. Here we test whether group I mGluRs require β-arrestin signalling during specific forms of plasticity at hippocampal excitatory synapses. We find that genetic ablation of β-arrestin2, but not β-arrestin1, results in deficits in plasticity mediated by mGlu1 receptors in CA3 pyramidal neu ...[more]