Ontology highlight
ABSTRACT:
SUBMITTER: Shin D
PROVIDER: S-EPMC3050664 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Shin Donghun D Lee Yoonsung Y Poss Kenneth D KD Stainier Didier Y R DY
Development (Cambridge, England) 20110401 7
Hepatic competence, or the ability to respond to hepatic-inducing signals, is regulated by a number of transcription factors broadly expressed in the endoderm. However, extrinsic signals might also regulate hepatic competence, as suggested by tissue explant studies. Here, we present genetic evidence that Fgf signaling regulates hepatic competence in zebrafish. We first show that the endoderm posterior to the liver-forming region retains hepatic competence: using transgenic lines that overexpress ...[more]