Mitochondrial-nuclear coadaptation revealed through mtDNA replacements in Saccharomyces cerevisiae.

ABSTRACT:

Background

Mitochondrial function requires numerous genetic interactions between mitochondrial- and nuclear- encoded genes. While selection for optimal mitonuclear interactions should result in coevolution between both genomes, evidence for mitonuclear coadaptation is challenging to document. Genetic models where mitonuclear interactions can be explored are needed.

Results

We systematically exchanged mtDNAs between 15 Saccharomyces cerevisiae isolates from a variety of ecological niches to create 225 unique mitochondrial-nuclear genotypes. Analysis of phenotypic profiles confirmed that environmentally-sensitive interactions between mitochondrial and nuclear genotype contributed to growth differences. Exchanges of mtDNAs between strains of the same or different clades were ju

SUBMITTER: Nguyen THM 

PROVIDER: S-EPMC7517635 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature