Ontology highlight
ABSTRACT:
SUBMITTER: Go YM
PROVIDER: S-EPMC3051281 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Go Young-Mi YM Jones Dean P DP
Methods in enzymology 20100620
Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals and become oxidized in disease. This oxidation affects the function of cell surface receptors, ion channels, and structural proteins. Downstream signaling due to changes in extracellular redox potential can be studied using a redox clamp in which thiol and disulfide concentrations are varied to obtain a series of controlled redox potentials. Previous applications of this approach show that cell prolifera ...[more]