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Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

ABSTRACT: Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

SUBMITTER: Dorr CR 

PROVIDER: S-EPMC3053071 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

Dorr Casey R CR   Yemets Sergiy S   Kolomitsyna Oksana O   Krasutsky Pavel P   Mansky Louis M LM  

Bioorganic & medicinal chemistry letters 20110101 1

Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation. ...[more]

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