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Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.


ABSTRACT: We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

SUBMITTER: Ewart GD 

PROVIDER: S-EPMC415615 | biostudies-other | 2004 Jun

REPOSITORIES: biostudies-other

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