Ontology highlight
ABSTRACT:
SUBMITTER: Skjaerven L
PROVIDER: S-EPMC3053311 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Skjaerven Lars L Grant Barry B Muga Arturo A Teigen Knut K McCammon J Andrew JA Reuter Nathalie N Martinez Aurora A
PLoS computational biology 20110310 3
GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized from extensive crystallographic studies. However, the link between the observed conformations and the mechanisms involved in the allosteric response to ATP and the nucleotide-driven reaction cycle are not completely established. Here we describe extensive (in total long) unbia ...[more]