Ontology highlight
ABSTRACT:
SUBMITTER: Rooney JP
PROVIDER: S-EPMC3053583 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Rooney John P JP Patil Ashish A Joseph Fraulin F Endres Lauren L Begley Ulrike U Zappala Maria R MR Cunningham Richard P RP Begley Thomas J TJ
Genomics 20101230 3
Cellular responses to DNA damage can prevent mutations and death. In this study, we have used high throughput screens and developed a comparative genomic approach, termed Functionome mapping, to discover conserved responses to UVC-damage. Functionome mapping uses gene ontology (GO) information to link proteins with similar biological functions from different organisms, and we have used it to compare 303, 311 and 288 UVC-toxicity modulating proteins from Escherichia coli, Schizosaccharomyces pomb ...[more]