Ontology highlight
ABSTRACT:
SUBMITTER: Istvan ES
PROVIDER: S-EPMC305622 | biostudies-literature | 2000 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20000301 5
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is controlled through synthesis, degradation and phosphorylation to maintain the concentration of mevalonate-derived products. In addition to the physiological regulation of HMGR, the human enzyme has been targeted successfully by drugs in the clinical treatment of high serum cholesterol levels. Three crystal structures of ...[more]