Ectodermal Wnt/?-catenin signaling shapes the mouse face.
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ABSTRACT:
SUBMITTER: Reid BS
PROVIDER: S-EPMC3057077 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Ectodermal Wnt/β-catenin signaling shapes the mouse face.
Reid Bethany S BS Yang Hui H Melvin Vida Senkus VS Taketo Makoto M MM Williams Trevor T
Developmental biology 20101116 2
The canonical Wnt/β-catenin pathway is an essential component of multiple developmental processes. To investigate the role of this pathway in the ectoderm during facial morphogenesis, we generated conditional β-catenin mouse mutants using a novel ectoderm-specific Cre recombinase transgenic line. Our results demonstrate that ablating or stabilizing β-catenin in the embryonic ectoderm causes dramatic changes in facial morphology. There are accompanying alterations in the expression of Fgf8 and Sh ...[more]
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