Ontology highlight
ABSTRACT:
SUBMITTER: Kaur K
PROVIDER: S-EPMC3057096 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Kaur Kirandeep K Jain Meenakshi M Khan Shabana I SI Jacob Melissa R MR Tekwani Babu L BL Singh Savita S Singh Prati Pal PP Jain Rahul R
Bioorganic & medicinal chemistry 20101125 1
In continuing our search of potent antimalarials based on 8-aminoquinoline structural framework, three series of novel bis(8-aminoquinolines) using convenient one to four steps synthetic procedures were synthesized. The bisquinolines were evaluated for in vitro antimalarial (Plasmodiumfalciparum), antileishmanial (Leishmaniadonovani), antimicrobial (a panel of pathogenic bacteria and fungi), cytotoxicity, β-hematin inhibitory and methemoglobin (MetHb) formation activities. Several compounds exhi ...[more]