Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC3057469 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Qi Xiaoxuan X Lan Shuiyun S Wang Wenjian W Schelde Lisa McLay LM Dong Haohao H Wallat Gregor D GD Ly Hinh H Liang Yuying Y Dong Changjiang C
Nature 20101117 7325
Lassa virus, the causative agent of Lassa fever, causes thousands of deaths annually and is a biological threat agent, for which there is no vaccine and limited therapy. The nucleoprotein (NP) of Lassa virus has essential roles in viral RNA synthesis and immune suppression, the molecular mechanisms of which are poorly understood. Here we report the crystal structure of Lassa virus NP at 1.80 Å resolution, which reveals amino (N)- and carboxy (C)-terminal domains with structures unlike any of the ...[more]