Ontology highlight
ABSTRACT:
SUBMITTER: Hastie KM
PROVIDER: S-EPMC3228486 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Hastie Kathryn M KM Liu Tong T Li Sheng S King Liam B LB Ngo Nhi N Zandonatti Michelle A MA Woods Virgil L VL de la Torre Juan Carlos JC Saphire Erica Ollmann EO
Proceedings of the National Academy of Sciences of the United States of America 20111114 48
Arenaviruses cause disease in industrialized and developing nations alike. Among them, the hemorrhagic fever virus Lassa is responsible for ~300,000-500,000 infections/y in Western Africa. The arenavirus nucleoprotein (NP) forms the protein scaffold of the genomic ribonucleoprotein complexes and is critical for transcription and replication of the viral genome. Here, we present crystal structures of the RNA-binding domain of Lassa virus NP in complex with ssRNA. This structure shows, in contrast ...[more]