Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC3057570 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Yang Xiaojun X Lin Xiaojuan X Zhong Xiaomin X Kaur Sippy S Li Ning N Liang Shun S Lassus Heini H Wang Liping L Katsaros Dionyssios D Montone Kathleen K Zhao Xia X Zhang Youcheng Y Bützow Ralf R Coukos George G Zhang Lin L
Cancer research 20101102 22
A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-like" subpopulation of tumor cells has the unique ability to initiate and perpetuate tumor growth; moreover, it is highly resistant to chemotherapy and significantly associated with poor clinical outcomes. The development of more effective therapies for cancer requires targeting of this cell population. Using cDNA microarray analysis, we identified that the expression of the Caenorhabditis elegans lin-28 homologue (LIN28) was ...[more]