Ontology highlight
ABSTRACT:
SUBMITTER: Suhren JH
PROVIDER: S-EPMC5357732 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell reports 20170301 10
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood. In the ciliated protozoan Tetrahymena, heterochromatin is formed exclusively on the sequences that are removed from the somatic genome by programmed DNA elimination, and an RNAi-mediated feedback loop is important for assembling heterochromatin on the eliminated sequences. In this study, we show that the heterochro ...[more]