Ontology highlight
ABSTRACT:
SUBMITTER: Sivasankaran R
PROVIDER: S-EPMC305821 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Sivasankaran R R Vigano M A MA Müller B B Affolter M M Basler K K
The EMBO journal 20001101 22
The gradient morphogen Decapentaplegic (Dpp) organizes pattern by inducing the transcription of different target genes at distinct threshold concentrations during Drosophila development. An important, albeit indirect, mode by which Dpp controls the spatial extent of its targets is via the graded downregulation of brinker, whose product in turn negatively regulates the expression of these targets. Here we report the molecular dissection of the cis-regulatory sequences of optomotor-blind (omb), a ...[more]