Ontology highlight
ABSTRACT:
SUBMITTER: Rasmussen SG
PROVIDER: S-EPMC3058308 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature 20110101 7329
G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human β(2) adrenergic receptor (β(2)AR) that exhibits G protein-like be ...[more]