Ontology highlight
ABSTRACT:
SUBMITTER: Che T
PROVIDER: S-EPMC5802374 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell 20180104 1-2
The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric, and analgesic activities. The design of KOP analgesics devoid of hallucinatory and dysphoric effects has been hindered by an incomplete structural and mechanistic understanding of KOP agonist actions. Here, we provide a crystal structure of human KOP in complex with the potent epoxymorphinan opioid agonist MP1104 and an active-state-stabilizing nanobody. Comparisons between inactive- and active-state opio ...[more]