Ontology highlight
ABSTRACT:
SUBMITTER: Tsai WW
PROVIDER: S-EPMC3058826 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Tsai Wen-Wei WW Wang Zhanxin Z Yiu Teresa T TT Akdemir Kadir C KC Xia Weiya W Winter Stefan S Tsai Cheng-Yu CY Shi Xiaobing X Schwarzer Dirk D Plunkett William W Aronow Bruce B Gozani Or O Fischle Wolfgang W Hung Mien-Chie MC Patel Dinshaw J DJ Barton Michelle Craig MC
Nature 20101201 7326
Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD) and ...[more]