Ontology highlight
ABSTRACT:
SUBMITTER: Yi C
PROVIDER: S-EPMC3058853 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Yi Chengqi C Jia Guifang G Hou Guanhua G Dai Qing Q Zhang Wen W Zheng Guanqun G Jian Xing X Yang Cai-Guang CG Cui Qiang Q He Chuan C
Nature 20101101 7321
Mononuclear iron-containing oxygenases conduct a diverse variety of oxidation functions in biology, including the oxidative demethylation of methylated nucleic acids and histones. Escherichia coli AlkB is the first such enzyme that was discovered to repair methylated nucleic acids, which are otherwise cytotoxic and/or mutagenic. AlkB human homologues are known to play pivotal roles in various processes. Here we present structural characterization of oxidation intermediates for these demethylases ...[more]