'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.
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ABSTRACT:
SUBMITTER: Kaneider NC
PROVIDER: S-EPMC3059149 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.
Kaneider Nicole C NC Leger Andrew J AJ Agarwal Anika A Nguyen Nga N Perides George G Derian Claudia C Covic Lidija L Kuliopulos Athan A
Nature immunology 20071028 12
Sepsis is a deadly disease characterized by considerable derangement of the proinflammatory, anti-inflammatory and coagulation responses. Protease-activated receptor 1 (PAR1), an important regulator of endothelial barrier function and blood coagulation, has been proposed to be involved in the lethal sequelae of sepsis, but it is unknown whether activation of PAR1 is beneficial or harmful. Using a cell-penetrating peptide (pepducin) approach, we provide evidence that PAR1 switched from being a va ...[more]
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