Ontology highlight
ABSTRACT:
SUBMITTER: Tressel SL
PROVIDER: S-EPMC3394510 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Tressel Sarah L SL Kaneider Nicole C NC Kasuda Shogo S Foley Caitlin C Koukos Georgios G Austin Karyn K Agarwal Anika A Covic Lidija L Opal Steven M SM Kuliopulos Athan A
EMBO molecular medicine 20110518 7
Sepsis is a deadly disease characterized by the inability to regulate the inflammatory-coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorly understood and has hampered the development of effective therapeutics. Matrix metalloproteases (MMPs) are involved in the host response to pathogens, but can also cause uncontrolled tissue damage and contribute to mortality. We found that human sepsis patients had markedly elevated plasma proMMP-1 and ...[more]