Ontology highlight
ABSTRACT:
SUBMITTER: Gibson P
PROVIDER: S-EPMC3059767 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Gibson Paul P Tong Yiai Y Robinson Giles G Thompson Margaret C MC Currle D Spencer DS Eden Christopher C Kranenburg Tanya A TA Hogg Twala T Poppleton Helen H Martin Julie J Finkelstein David D Pounds Stanley S Weiss Aaron A Patay Zoltan Z Scoggins Matthew M Ogg Robert R Pei Yanxin Y Yang Zeng-Jie ZJ Brun Sonja S Lee Youngsoo Y Zindy Frederique F Lindsey Janet C JC Taketo Makoto M MM Boop Frederick A FA Sanford Robert A RA Gajjar Amar A Clifford Steven C SC Roussel Martine F MF McKinnon Peter J PJ Gutmann David H DH Ellison David W DW Wechsler-Reya Robert R Gilbertson Richard J RJ
Nature 20101208 7327
Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour subtypes that together comprise the most common malignant childhood brain tumour. These tumours are thought to arise within the cerebellum, with approximately 25% originating from granule neuron precursor cells (GNPCs) after aberrant activation of the Sonic Hedgehog pathway (hereafter, SHH subtype). The pathological processes that drive heterogeneity among the other medulloblastoma subtypes are not known, hinde ...[more]