Ontology highlight
ABSTRACT:
SUBMITTER: Hailey DW
PROVIDER: S-EPMC3059894 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Hailey Dale W DW Rambold Angelika S AS Satpute-Krishnan Prasanna P Mitra Kasturi K Sougrat Rachid R Kim Peter K PK Lippincott-Schwartz Jennifer J
Cell 20100501 4
Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in understanding the molecular basis of this process, the membrane origin of autophagosomes remains unclear. Here, we demonstrate that, in starved cells, the outer membrane of mitochondria participates in autophagosome biogenesis. The early autophagosomal marker, Atg5, transiently localizes to punctae on mitochondria, followed ...[more]