Ontology highlight
ABSTRACT:
SUBMITTER: Bejarano E
PROVIDER: S-EPMC4008708 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nature cell biology 20140406 5
The plasma membrane contributes to the formation of autophagosomes, the double-membrane vesicles that sequester cytosolic cargo and deliver it to lysosomes for degradation during autophagy. In this study, we have identified a regulatory role for connexins (Cx), the main components of plasma membrane gap junctions, in autophagosome formation. We have found that plasma-membrane-localized Cx proteins constitutively downregulate autophagy through a direct interaction with several autophagy-related p ...[more]