Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum.
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ABSTRACT:
SUBMITTER: Zakhari JS
PROVIDER: S-EPMC3060279 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
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Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum.
Zakhari Joseph S JS Kinoyama Isao I Struss Anjali K AK Pullanikat Prasanna P Lowery Colin A CA Lardy Matthew M Janda Kim D KD
Journal of the American Chemical Society 20110224 11
The triphenyl amide/ester 12 was originally reported to be a potent mimic of the natural 3-oxo-dodecanoyl homoserine lactone quorum sensing molecule in Pseudomonas aeruginosa. However, explicit synthesis/chemical characterization was lacking, and a later report providing protein crystallographic data inferred 12 to be incorrect, with 9 now being the surmised structure. Because of these inconsistencies and our interest in quorum sensing molecules utilized by gram-negative bacteria, we found it ne ...[more]
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