Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Villalobos RA
PROVIDER: S-EPMC3060439 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Gonzalez-Villalobos Romer A RA Billet Sandrine S Kim Catherine C Satou Ryousuke R Fuchs Sebastien S Bernstein Kenneth E KE Navar L Gabriel LG
Journal of the American Society of Nephrology : JASN 20101129 3
The contribution of the intrarenal renin-angiotensin system to the development of hypertension is incompletely understood. Here, we used targeted homologous recombination to generate mice that express angiotensin-converting enzyme (ACE) in the kidney tubules but not in other tissues. Mice homozygous for this genetic modification (ACE 9/9 mice) had low BP levels, impaired ability to concentrate urine, and variable medullary thinning. In accord with the ACE distribution, these mice also had reduce ...[more]