Ontology highlight
ABSTRACT:
SUBMITTER: Ragab A
PROVIDER: S-EPMC3061042 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Ragab Anan A Buechling Tina T Gesellchen Viola V Spirohn Kerstin K Boettcher Anna-Lisa AL Boutros Michael M
The EMBO journal 20110204 6
Immune signalling pathways need to be tightly regulated as overactivation of these pathways can result in chronic inflammatory diseases and cancer. NF-κB signalling and associated innate immune pathways are crucial in the first line of defense against infection in all animals. In a genome-wide RNAi screen for modulators of Drosophila immune deficiency (IMD)/NF-κB signalling, we identified components of the Ras/MAPK pathway as essential for suppression of IMD pathway activity, even in the absence ...[more]