Ontology highlight
ABSTRACT:
SUBMITTER: Petrova T
PROVIDER: S-EPMC7044202 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Petrova Tsvetana T Pesic Jelena J Pardali Katerina K Gaestel Matthias M Arthur J Simon C JSC
Scientific reports 20200226 1
Type 2 Innate lymphoid cells (ILC2s) are implicated in helminth infections and asthma where they play a role in the production of Th2-type cytokines. ILC2s express the IL-33 receptor and are a major cell type thought to mediate the effects of this cytokine in vivo. To study the signalling pathways that mediate IL-33 induced cytokine production, a culture system was set up to obtain pure populations of ILC2s from mice. Inhibitors of the p38α/β and ERK1/2 MAPK pathways reduced the production of IL ...[more]