Ontology highlight
ABSTRACT:
SUBMITTER: Mazan-Mamczarz K
PROVIDER: S-EPMC3062410 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Mazan-Mamczarz Krystyna K Hagner Patrick R PR Zhang Yongqing Y Dai Bojie B Lehrmann Elin E Becker Kevin G KG Keene Jack D JD Gorospe Myriam M Liu Zhenqui Z Gartenhaus Ronald B RB
Blood 20110105 8
Maintenance of genomic stability depends on the DNA damage response, a biologic barrier in early stages of cancer development. Failure of this response results in genomic instability and high predisposition toward lymphoma, as seen in patients with ataxia-telangiectasia mutated (ATM) dysfunction. ATM activates multiple cell-cycle checkpoints and DNA repair after DNA damage, but its influence on posttranscriptional gene expression has not been examined on a global level. We show that ionizing rad ...[more]