Ontology highlight
ABSTRACT:
SUBMITTER: Schellinger JG
PROVIDER: S-EPMC3062786 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20110222 10
A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthet ...[more]