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A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation.

ABSTRACT: A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF(4) catalyst. The synthetic route provides the advantage of less synthetic steps, proceeds with high yields and enantioselectivity, and avoids hazardous reaction conditions.

SUBMITTER: Sammet B

PROVIDER: S-EPMC3063055 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation.

Sammet Benedikt B Brax Mathilde M Sewald Norbert N

Beilstein journal of organic chemistry 20110222

A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF(4) catalyst. The synthetic route provides the advantage of less synthetic steps, proceeds with high yields and enantioselectivity, and avoids hazardous reaction conditions. ...[more]

PMID: 21448253

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